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Once a multi-dose vial has been punctured for the first use, it is generally recommended to discard any remaining solution after approximately 28 days for sterility reasons, even if this falls within the original beyond-use date

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Van Schooten FJ, Besaratinia A, De Flora S, DAgostini F, Izzotti A, Camoirano A, Balm AJ, Dallinga JW, Bast A, Haenen GR, Vant Veer L, Baas P, Sakai H, Van Zandwijk N (2002) Effects of oral administration of N-acetyl-L-cysteine: a multi-biomarker study in smokers